Correlations between clinical manifestation in patients with primary and secondary fibromyalgia


  • Valentina Reshkova UMHAT „St.Ivan Rilski”; Medical university – Sofia


primary and secondary fibromyalgia, SLE, osteoarthritis


Fibromyalgia (FM) is widespread and covers different age groups, most commonly occurring between 20 and 50 years. Patients with rheumatic diseases – osteoarthritis (OA) and systemic lupus erythematosus (SLE), have an accompanying/ secondary FM. The presence of secondary fibromyalgia in SLE and OA has been investigated by various authors and is found in approximately 20% of these patients.
The purpose of this clinical trial is to analyze correlations under clinical manifestations of primary vs. secondary FM. The present study is prospective and has been performed at the
Clinic of Rheumatology of the University Hospital „St. Ivan Rilski” and „Focus 5” Center, Sofia for the period September 2013 – September 2017. Eighty three patients with primary FM, 39 patients with FM + OA, 23 patients with FM + SLE, 27 patients with SLE and 36 healthy subjects were included. The present study compared chronic pain, depression and anxiety in patients with primary FM, and patients with SLE, OA and secondary FM. The comparison between the patient groups is important for the evaluation of the disease activity and the treatment that will be recommended.


Reshkova, V. Izsledvane na boleznenite tochki pri bolni s fibromialgiya, lechenie s razlichni pidinemerum Disertatsiya za pridobivane na nauchno-obrazovatelnata stepen „Doktor”, gr. Sofiya, 2013

Ana Luiza, P., Kasemodel de Araujo, Paliares, I. C., Novo, N. F. The association of fibromyalgia and systemic lupus erythematosus change the presentation and severity of both diseases? Rv bras Rheumatol, 2015, 55 (1) 37-42.

Marchione, V. Fibromyalgia pain and osteoarthritis linked in how brain experiences chronic pain, Arthritis Research Facility, 2016, 5.

Thomas, E., Blotman, F. Prise en charge de la fibromyalgie. Refl Rhum, 2002, 9-14.

Wolfe, F., Crauw, D. J., Fitzcharles, M. A. et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken), 2010, 62, 600-610.

Wolfe, F. New American College of Rheumatology criteria for fibromyalgia: a twenty-year journey. Arthritis Care Res (Hoboken), 2010, 62, 583-584.

Yilmaz, H., Karaca, G., Demir Polat, H., Akkurt, H. Comparison between depression levels of women with knee osteoarthritis, rheumatoid arthritis, and fibromyalgia syndrome: a controlled study. Turk J Phys med rehab, 2015, 61, 197-202.

Zautra, A., Fasman, R., Parish, B., Davis, M. Daily Fatigue in women with osteoarthritis, rheumatoid arthritis, and fibromyalgia. Pain, 2007, 128-135.



How to Cite

Reshkova, V. “Correlations Between Clinical Manifestation in Patients With Primary and Secondary Fibromyalgia”. Cephalgia, vol. 22, no. 1, Nov. 2020, pp. 15-22,