Efficacy and safety of Tiyozid (thiocolchicoside) in patients with acute low back pain
Keywords:
low back pain, thiocolchicoside, treatmentAbstract
Introduction: Low back pain back is one of the most frequent and disabling conditions to visit a neurologist and is the leading cause of impaired daily activity at young people. However, in some patients, we need additional options to manage the acute pain. Additional treatment options should be sought.
Aim: To evaluate the effect and tolerability of thiocolchicoside (Tiyozid) tablets and I.m. ampoules in acute low back pain.
Patients and methods: Three groups of patients were studied – on treatment with thiocolchicoside ampoules, on treatment with thiocolchicoside tablets and a control group on treatment with NSAID – flurbiprofen.
Results: A comparable analgesic effect was found in all the groups - with flurbiprofen, thiocolchicoside tablets and thiocolchicoside ampoules. The choice of a given medication should be determined by the patient's specific profile.
In conclusion, thiocolchicoside is effective, with very good tolerability and no significant side effects in patients with acute low back pain. It can be recommended as a good alternative to NSAIDs, especially in the absence of effect or in the presence of contraindications to the use of other medications.
Thiocolchicoside could be administered as tablets or as intramuscular injections, both as monotherapy or in combination with corticosteroids or NSAIDs.
References
Bogdanova, D., Ilieva, P., Todorov, V., & Milanov, I. (2020). Clinical study of the efficacy and safety with combination flurbiprofen and pregabalin in patients with neck/low back pain. Cephalgia, 22(1), 23–29. Retrieved from https://glavobolie.org/journal/index.php/ce/article/view/3
Milanov, I. (2015). National Consensus on Diagnosis and Treatment of Pain from Neurological Disorders: 2015. Cephalgia, 17(S1), 9–64. Retrieved from https://glavobolie.org/journal/index.php/ce/article/view/35
[Milanov, I. Bolki v gŭrba V: Bolka, vtoro preraboteno izdanie, Steno, Varna, 2020, 88-90.]
Balduini, W., Cimino, M., Depoortere, H., Cattabeni, F. Characterization of [3H]thiocolchicoside binding sites in rat spinal cord and cerebral cortex. Eur J Pharmacol. 1999, 376, 149-157.
Balduini, W., De Angelis, V., Mazzoni, E., Depoortere, H., Cattabeni, F., Cimino, M. Autoradiographic localization of [3H]thiocolchicoside binding sites in the rat brain and spinal cord. Neuropharmacology, 2001, 40, 1044-1049.
Biziere, K., Huguet, F., Narcisse, G., Breteau, M. Affinity of thiocolchicoside and thiocolchicoside analogues for the postsynaptic GABA receptor site. Eur J Pharmacol., 1981, 75, 167-168.
Cimino, M., Marini, P., Cattabeni, F. Interaction of thiocolchicoside with [3H]strychnine binding sites in rat spinal cord and brainstem. Eur J Pharmacol. 1996, 318, 201-204.
International Association for the Study of Pain (IASP) taxonomy https://www.iasp-pain.org/resources/terminology/
Janbroers, J.M. Review of the toxicology, pharmacodynamics and pharmacokinetics of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions. Acta Therapeutica, 1987, 13, 221-235.
Kasapoglu, M.B., Cebi, A.T. Randomized split-mouth study for evaluating the efficacy of nimesulide and nimesulide + Thiocolchicoside combination following impacted mandibular third molar surgery. Niger J Clin Pract., 2022, 25(5), 641-646.
Ketenci, A., Ozcan, E., Karamursel, S. Assessment of efficacy and psychomotor perf ormances of thiocolchicoside and tizanidine in patients with acute low back pain. Int J Clin Pract., 2005, 59, 764-770.
Kumar, S., Rani, S., Siwach, R., Verma, P. To compare the efficacy and safety of fixed dose combination of thiocolchicoside and aceclofenac versus chlorzoxazone, aceclofenac and paracetamol in patients with acute lower backache associated with muscle spasm. Int J Appl Basic Med Res, 2014, 4, 101-105.
Lahoti, G. To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain. J Indian Med Assoc., 2012, 110(1), 56-58.
Reuter, S., Prasad, S., Phromnoi, K., Ravindran, J., Sung, B., Yadav, V.R., Kannappan, R., Chaturvedi, M.M., Aggarwal, B.B. Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer. Cancer Prev Res (Phila), 2010, 3(11), 1462-1472.
Soonawalla, D.F., Joshi, N. Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm. J Indian Med Assoc., 2008, 106, 331-335.
Sproviero, E., Albamonte, E., Costantino, C., Giossi, A., Mancuso, M., Rigamonti, A., Tornari, P., Caggiano, G. Efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg in the treatment of acute low back pain: a phase III, randomized, double blind, controlled trial. Eur J Phys Rehabil Med., 2018, 54(5), 654-662.
Tüzün, F., Unalan, H., Oner, N., Ozgüzel, H., Kirazli, Y., Içağasioğlu, A., Kuran, B., Tüzün, S., Başar, G. Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain. Joint Bone Spine, 2003, 70(5), 356-361.
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